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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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11beta-Hydroxyprogesterone is a potent inhibitor of 11β-Hydroxysteroid dehydrogenase. It activates the human mineralocorticoid receptor in COS-7 cells (ED50 of 10 nM) and exhibits agonist mineralocorticoid activity by activating the transiently expressed human mineralocorticoid receptor (hMR) in COS-7 cells. Its agonist activity is linked to contacts between its 11β-hydroxyl group and Asn770 within the hMR-ligand-binding domain.
Potent inhibitor of 11β-Hydroxysteroid dehydrogenase.
Activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM.
Displays agonist mineralocorticoid activity.
Exhibits hypertensinogenic activity in rats, dependent on an intact adrenal and mineralocorticoid receptor activation.
Classified as an endogenous metabolite and a steroid.
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